We compared the antihypertensive efficacy of once-daily amlodipine (AM) versus
nitrendipine (NTR) by 24-h ambulatory blood pressure monitoring (24-h ABPM) in 32
patients with mild to moderate essential hypertension (EH). After a 2-week single-blind,
placebo run-in period, patients were randomized in a double-blind, parallel fashion: 14
received AM 5 mg and 18 NTR 10 mg. After 2 weeks, dose was adjusted if necessary (AM
10 mg or NTR 20 mg) and continued for another 6-week period. At the end of the placebo …

In this single-blind crossover study the antihypertensive efficacies of two dihydropyridine
calcium antagonists, sustained-release isradipine and lacidipine, were compared using
clinic and ambulatory blood-pressure measurements. After a 2-week placebo wash-out, 34
patients (19 men, 15 women, mean age 49 years) with mild to moderate hypertension
(diastolic blood pressure range 95–110 mmHg) were treated with 5 mg sustained-release
isradipine for 4 weeks and 4 mg lacidipine for 4 weeks in a random order. Medications were …